Staffordshire Fire and Rescue Service responded to reports of a road traffic collision on Park Hall Road, Stoke-on-Trent.
At around 9:51am, two vehicles were involved in a collision. Both occupants were trapped.
Crews from Hanley, Longton and Newcastle attended the scene alongside West Midlands Ambulance Service.
Both occupants were rescued from their vehicles at 10:48am. They were treated by paramedics at the scene and taken by ambulance to Royal Stoke University Hospital. An air ambulance also attended the incident.